Part:BBa_K4165206
Coh2 linked with tau binding peptide (M4W39)
Fusion protein consists of Tau binding peptide (M4W39) for tau targeting and Coh2 protein [BBa_K4165003] that bind to Docs [BBa_K3396000] to form the protac system.
Usage and Biology
DOC - CoH system was used for many targeting biological applications . In our case we introduce a fusion protein with Tau binding peptide (M4W39) for targeting Tau with different methods so aggregations inhibition can be further tested in vivo using this part.
Sequence and Features
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]
3D Model Photo and ranking
This fused protein was modeled using RosettaFold software and after running our quality assessment code it got a score of 4 out of 6 according to the parameters of the QA code: C-beta deviations, clash score, Molprobity, Ramachandran favored, Ramachandran outliers, Q mean 4, and Q mean 6. This protein was excluded due to its low QA score as compared to other models
Figure 1. Predicted 3D structure of CoH2-(G4S)3-M4W39 protein Visualized by Pymol.
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